[HTML][HTML] Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation
Highlights•Histone acetyltransferase Kat6b is highly expressed in hematopoietic stem
cells•KAT6B expression is reduced in hematopoietic stem cells with aging•Reduced Kat6b
causes decreased erythropoietic activity and increased myeloid differentiationAged
hematopoietic stem cells (HSCs) undergo biased lineage priming and differentiation toward
production of myeloid cells. A comprehensive understanding of gene regulatory
mechanisms causing HSC aging is needed to devise new strategies to sustainably improve …
cells•KAT6B expression is reduced in hematopoietic stem cells with aging•Reduced Kat6b
causes decreased erythropoietic activity and increased myeloid differentiationAged
hematopoietic stem cells (HSCs) undergo biased lineage priming and differentiation toward
production of myeloid cells. A comprehensive understanding of gene regulatory
mechanisms causing HSC aging is needed to devise new strategies to sustainably improve …
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